Negative / Null Result Report2018
Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level
JAMA
Failure-mode index
Negative results in Immunology and Microbiology
87 indexed negative results, null findings, and replication failures in Immunology and Microbiology. Each entry is a real published study whose primary finding was negative — learn what already failed before you repeat it.
Most-cited failures in Immunology and Microbiology
Negative / Null Result Report2010
Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections
PLoS Pathogens
Negative / Null Result Report2020
BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
Proceedings of the National Academy of Sciences
Negative / Null Result Report2012
Effects of Bacillus subtilis on the growth performance, digestive enzymes, immune gene expression and disease resistance of white shrimp, Litopenaeus vannamei
Fish & Shellfish Immunology
Negative / Null Result Report2010
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
Human Molecular Genetics
Negative / Null Result Report2014
Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
mBio
Negative / Null Result Report2010
COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function
BMC Cancer
Negative / Null Result Report2010
Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial
BMJ
Negative / Null Result Report2016
Incidence, prevalence and mortality of patients with psoriasis: a U.K. population-based cohort study
British Journal of Dermatology
Negative / Null Result Report2013
Nonmedical Vaccine Exemptions and Pertussis in California, 2010
PEDIATRICS
Failed Experiment Report2018
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response
Journal of Clinical Investigation
Negative / Null Result Report2011
Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37
Frontiers in Microbiology
Negative / Null Result Report2021
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
Nature Communications
Negative / Null Result Report2013
The Impact of a School-Based Hygiene, Water Quality and Sanitation Intervention on Soil-Transmitted Helminth Reinfection: A Cluster-Randomized Trial
American Journal of Tropical Medicine and Hygiene
Negative / Null Result Report2010
Therapeutic Cancer Vaccines in Prostate Cancer: The Paradox of Improved Survival Without Changes in Time to Progression
The Oncologist
Negative / Null Result Report2015
Re-analysis of health and educational impacts of a school-based deworming programme in western Kenya: a pure replication
International Journal of Epidemiology
Negative / Null Result Report2018
Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck
JAMA Oncology
Negative / Null Result Report2010
Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
British Journal of Cancer
Negative / Null Result Report2012
Quantification of piscine reovirus (PRV) at different stages of Atlantic salmon Salmo salar production
Diseases of Aquatic Organisms
Negative / Null Result Report2017
Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease
Journal of Clinical Investigation
Failed Experiment Report2023
Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma
Science Translational Medicine
Negative / Null Result Report2010
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
Journal of Clinical Investigation
Negative / Null Result Report2013
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling
The Journal of Immunology
Negative / Null Result Report2015
Effect of Dried Blood Spot Quality on Newborn Screening Analyte Concentrations and Recommendations for Minimum Acceptance Criteria for Sample Analysis
Clinical Chemistry
Negative / Null Result Report2019
Current clinical practice and challenges in the management of secondary immunodeficiency in hematological malignancies
European Journal Of Haematology
Negative / Null Result Report2024
Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients
Genome Medicine
Negative / Null Result Report2012
After TGN1412: Recent developments in cytokine release assays
Journal of Immunotoxicology
Negative / Null Result Report2021
Small molecule STING inhibition improves myocardial infarction remodeling
Life Sciences
Negative / Null Result Report2020
Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial
British Journal of Cancer
Negative / Null Result Report2015
Identification and Functional Characterization of the Novel Edwardsiella tarda Effector EseJ
Infection and Immunity
Negative / Null Result Report2020
Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity
Journal for ImmunoTherapy of Cancer
Negative / Null Result Report2013
Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain
Proceedings of the National Academy of Sciences
Negative / Null Result Report2015
Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis
PLoS ONE
Negative / Null Result Report2010
Functionally Significant Differences in Expression of Disease-Associated IL-7 Receptor α Haplotypes in CD4 T Cells and Dendritic Cells
The Journal of Immunology
Negative / Null Result Report2021
Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019
Clinical & Translational Immunology
Negative / Null Result Report2010
Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation
The Journal of Experimental Medicine
Negative / Null Result Report2024
Adjuvant dendritic cell therapy in stage IIIB/C melanoma: the MIND-DC randomized phase III trial
Nature Communications
Negative / Null Result Report2015
The determinant of periodicity in Mycoplasma pneumoniae incidence: an insight from mathematical modelling
Scientific Reports
Negative / Null Result Report2021
TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood
EBioMedicine
Negative / Null Result Report2016
Comparing identified and statistically significant lipids and polar metabolites in 15‐year old serum and dried blood spot samples for longitudinal studies
Rapid Communications in Mass Spectrometry
Negative / Null Result Report2011
Penaeus monodon is protected against gill- associated virus by muscle injection but not oral delivery of bacterially expressed dsRNAs
Diseases of Aquatic Organisms
Negative / Null Result Report2019
Secretion of Mast Cell Inflammatory Mediators Is Enhanced by CADM1-Dependent Adhesion to Sensory Neurons
Frontiers in Cellular Neuroscience
Negative / Null Result Report2024
Interferons and interferon-related pathways in heart disease
Frontiers in Cardiovascular Medicine
Negative / Null Result Report2019
The role of endothelial MERTK during the inflammatory response in lungs
PLoS ONE
Negative / Null Result Report2014
Acute Sleep Deprivation Enhances Post-Infection Sleep and Promotes Survival during Bacterial Infection inDrosophila
SLEEP
Negative / Null Result Report2011
Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes
Cell Death and Disease
Negative / Null Result Report2010
Evaluation of host genetic and viral factors as surrogate markers for HTLV‐1‐associated myelopathy/tropical spastic paraparesis in Peruvian HTLV‐1‐infected patients
Journal of Medical Virology
Negative / Null Result Report2016
Education on tick bite and Lyme borreliosis prevention, aimed at schoolchildren in the Netherlands: comparing the effects of an online educational video game versus a leaflet or no intervention
BMC Public Health
Failed Experiment Report2020
Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC)
OncoImmunology
Negative / Null Result Report2016
Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
Oncotarget