Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity
Henrique Lemos; Rong Ou; Caroline McCardle; Yijun Lin; J Calver; Jack Minett; Ahmed Chadli; Lei Huang · 2020 · Journal for ImmunoTherapy of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor immunity against immunogenic tumors in mice, prompting clinical trials to test STING activators. However, STING signaling in the tumor microenvironment (TME) during development of Lewis lung carcinoma (LLC) suppresses antitumor immunity to promote tumor growth. We hypothesized that local immune balance favoring suppression of antitumor immunity also attenuates antitumor responses following STING activation. The purpose of this study was to evaluate how STING activation impacts antitumor responses in mic
Abstract by Henrique Lemos; Rong Ou; Caroline McCardle; Yijun Lin; J Calver; Jack Minett; Ahmed Chadli; Lei Huang, Journal for ImmunoTherapy of Cancer (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1136/jitc-2020-001182