Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections
Jacob D. Estes; Levelle D. Harris; Nichole R. Klatt; Brian Tabb; Stefania Pittaluga; Mirko Paiardini; Gayle Barclay; Jeremy Smedley · 2010 · PLoS Pathogens
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than either plasma viral load or CD4(+) T cell count. Recently, translocation of microbial products from the gastrointestinal tract has been proposed as an underlying cause of this immune activation, based on indirect evidence including the detection of microbial products and specific immune responses in the plasma of chronically HIV-infected humans or SIV-infected Asian macaques. We analyzed tissues from SIV-infected rhesus macaques (RMs) to pro
Abstract by Jacob D. Estes; Levelle D. Harris; Nichole R. Klatt; Brian Tabb; Stefania Pittaluga; Mirko Paiardini; Gayle Barclay; Jeremy Smedley, PLoS Pathogens (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.ppat.1001052