Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
Marieke J Bart; Simon R. Harris; Abdolreza Advani; Yoshichika Arakawa; Daniela Bottero; Valérie Bouchez; Pamela K. Cassiday; Chuen‐Sheue Chiang · 2014 · mBio
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen adaptation is suggested by antigenic divergence between vaccine strains and circulating strains and by the emergence of strains with increased pertussis toxin production. We applied com
Abstract by Marieke J Bart; Simon R. Harris; Abdolreza Advani; Yoshichika Arakawa; Daniela Bottero; Valérie Bouchez; Pamela K. Cassiday; Chuen‐Sheue Chiang, mBio (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1128/mbio.01074-14