The role of endothelial MERTK during the inflammatory response in lungs
Yitong Li; Erika S. Wittchen; Elizabeth Monaghan-Benson; Cornelia Hahn; H. Shelton Earp; Claire M. Doerschuk; Keith Burridge · 2019 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
As a key homeostasis regulator in mammals, the MERTK receptor tyrosine kinase is crucial for efferocytosis, a process that requires remodeling of the cell membrane and adjacent actin cytoskeleton. Membrane and cytoskeletal reorganization also occur in endothelial cells during inflammation, particularly during neutrophil transendothelial migration (TEM) and during changes in permeability. However, MERTK's function in endothelial cells remains unclear. This study evaluated the contribution of endothelial MERTK to neutrophil TEM and endothelial barrier function. In vitro experiments using primary
Abstract by Yitong Li; Erika S. Wittchen; Elizabeth Monaghan-Benson; Cornelia Hahn; H. Shelton Earp; Claire M. Doerschuk; Keith Burridge, PLoS ONE (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0225051