Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
Luuk van Hooren; Alessandra Vaccaro; Mohanraj Ramachandran; Konstantinos Vazaios; Sylwia Libard; Tiarne van de Walle; Maria Georganaki; Hua Huang · 2021 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of αCD40 induces hypofunctional T cells and impairs the response t
Abstract by Luuk van Hooren; Alessandra Vaccaro; Mohanraj Ramachandran; Konstantinos Vazaios; Sylwia Libard; Tiarne van de Walle; Maria Georganaki; Hua Huang, Nature Communications (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-021-24347-7