Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients
Xiuli Zhang; S. Peter Goedegebuure; Michael Y. Chen; Rashmi Mishra; Felicia Zhang; Yafei Yu; Kartik Singhal; Lijin Li · 2024 · Genome Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II epitopes and performed a phase 1 clinical trial in triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy, a patient population at high risk of disease recurrence. METHODS: Expressed somatic mutations were identified by tumor/normal exome sequencing and tumor RNA sequencing. The pVACtools sof
Abstract by Xiuli Zhang; S. Peter Goedegebuure; Michael Y. Chen; Rashmi Mishra; Felicia Zhang; Yafei Yu; Kartik Singhal; Lijin Li, Genome Medicine (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13073-024-01388-3