Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial
on behalf of the Vx-001-201 trial team; Cesare Gridelli; Tudor–Eliade Ciuleanu; Manuel Dómine; Aleksandra Szczęsna; Isabel Bover; Manuel Cobo; Nikolaos Kentepozidis · 2020 · British Journal of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with advanced/metastatic non-small cell lung cancer (NSCLC). METHODS: A randomised, double blind, phase 2b trial, in HLA-A*201-positive patients with metastatic, TERT-expressing NSCLC, who did not progress after first-line platinum-based chemotherapy were randomised to receive either Vx-001 or placebo. The primary endpoint of the trial was OS. RESULTS: Two hundred and twenty-one patients were randomised and 190 (101 and 89 patients in the placebo and the Vx-001 arm, respectiv
Abstract by on behalf of the Vx-001-201 trial team; Cesare Gridelli; Tudor–Eliade Ciuleanu; Manuel Dómine; Aleksandra Szczęsna; Isabel Bover; Manuel Cobo; Nikolaos Kentepozidis, British Journal of Cancer (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41416-020-0785-y