Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis
Cristiano Xavier Lima; Danielle G. Souza; Flávio A. Amaral; Caio T. Fagundes; Irla Paula Stopa Rodrigues; José C. Alves‐Filho; Marie Kosco‐Vilbois; Walter Ferlin · 2015 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
INTRODUCTION: Toll-like receptors (TLRs) play an important role in the recognition of microbial products and in host defense against infection. However, the massive release of inflammatory mediators into the bloodstream following TLR activation following sepsis is thought to contribute to disease pathogenesis. METHODS: Here, we evaluated the effects of preventive or therapeutic administration of monoclonal antibodies (mAbs) targeting either TLR2 or TLR4 in a model of severe polymicrobial sepsis induced by cecal ligation and puncture in mice. RESULTS: Pre-treatment with anti-TLR2 or anti-TLR4 m
Abstract by Cristiano Xavier Lima; Danielle G. Souza; Flávio A. Amaral; Caio T. Fagundes; Irla Paula Stopa Rodrigues; José C. Alves‐Filho; Marie Kosco‐Vilbois; Walter Ferlin, PLoS ONE (2015) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level
Negative / Null Result ReportDamaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections
Negative / Null Result ReportEffects of Bacillus subtilis on the growth performance, digestive enzymes, immune gene expression and disease resistance of white shrimp, Litopenaeus vannamei
Negative / Null Result ReportBCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
Negative / Null Result ReportFucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
Negative / Null Result ReportGlobal Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1371/journal.pone.0132336