Adjuvant dendritic cell therapy in stage IIIB/C melanoma: the MIND-DC randomized phase III trial
Kalijn F. Bol; Gerty Schreibelt; Martine Bloemendal; Wouter W. van Willigen; Simone Hins-de Bree; Anna L. de Goede; Annemiek J. de Boer; Kevin Bos · 2024 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall surv
Abstract by Kalijn F. Bol; Gerty Schreibelt; Martine Bloemendal; Wouter W. van Willigen; Simone Hins-de Bree; Anna L. de Goede; Annemiek J. de Boer; Kevin Bos, Nature Communications (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-024-45358-0