Negative / Null Result Report2013
Power and Predictive Accuracy of Polygenic Risk Scores
PLoS Genetics
Failure-mode index
Negative results in Biochemistry, Genetics and Molecular Biology
414 indexed negative results, null findings, and replication failures in Biochemistry, Genetics and Molecular Biology. Each entry is a real published study whose primary finding was negative — learn what already failed before you repeat it.
Most-cited failures in Biochemistry, Genetics and Molecular Biology
Negative / Null Result Report2010
Locoregional Recurrence After Sentinel Lymph Node Dissection With or Without Axillary Dissection in Patients With Sentinel Lymph Node Metastases
Annals of Surgery
Negative / Null Result Report2015
Critical aspects of using bacterial cell viability assays with the fluorophores SYTO9 and propidium iodide
BMC Microbiology
Negative / Null Result Report2020
Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2–negative advanced breast cancer: final overall survival results from SOLAR-1
Annals of Oncology
Negative / Null Result Report2011
A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy
Brain
Negative / Null Result Report2019
The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
Genome biology
Negative / Null Result Report2017
Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease
Journal of Gastroenterology
Negative / Null Result Report2013
Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice
Genome biology
Negative / Null Result Report2017
Seasonal, spatial, and maternal effects on gut microbiome in wild red squirrels
Microbiome
Negative / Null Result Report2013
Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
Aging Cell
Negative / Null Result Report2019
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA -Related Cancer
JAMA
Negative / Null Result Report2014
Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome
JAMA
Negative / Null Result Report2016
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Proceedings of the National Academy of Sciences
Negative / Null Result Report2015
Marked seasonal variation in the wild mouse gut microbiota
The ISME Journal
Negative / Null Result Report2017
Multi-tissue DNA methylation age predictor in mouse
Genome biology
Negative / Null Result Report2011
The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study
PLoS Genetics
Negative / Null Result Report2011
Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood
Epigenetics
Negative / Null Result Report2010
Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Arteriosclerosis Thrombosis and Vascular Biology
Negative / Null Result Report2012
miRmap: Comprehensive prediction of microRNA target repression strength
Nucleic Acids Research
Negative / Null Result Report2015
Investigation of the Association Between the Fecal Microbiota and Breast Cancer in Postmenopausal Women: a Population-Based Case-Control Pilot Study
JNCI Journal of the National Cancer Institute
Negative / Null Result Report2019
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
BMC Genomics
Negative / Null Result Report2018
Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E
Cell Death and Disease
Negative / Null Result Report2010
Formation and dissociation of M 1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules
Proceedings of the National Academy of Sciences
Negative / Null Result Report2017
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
PLoS Genetics
Negative / Null Result Report2019
Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression
EBioMedicine
Negative / Null Result Report2013
Genomic BLUP Decoded: A Look into the Black Box of Genomic Prediction
Genetics
Negative / Null Result Report2012
The role of crystallization and phase separation in the formation of physically cross-linked PVA hydrogels
Soft Matter
Negative / Null Result Report2014
Varespladib and Cardiovascular Events in Patients With an Acute Coronary Syndrome
JAMA
Negative / Null Result Report2012
A Three-Gene Model to Robustly Identify Breast Cancer Molecular Subtypes
JNCI Journal of the National Cancer Institute
Negative / Null Result Report2017
A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression
Australian & New Zealand Journal of Psychiatry
Negative / Null Result Report2010
Cell density and mobility protect swarming bacteria against antibiotics
Proceedings of the National Academy of Sciences
Negative / Null Result Report2011
DNA methylation profiles of human active and inactive X chromosomes
Genome Research
Negative / Null Result Report2011
Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project
PLoS Genetics
Negative / Null Result Report2013
Positively Charged Residues Are the Major Determinants of Ribosomal Velocity
PLoS Biology
Negative / Null Result Report2022
Exaggerated false positives by popular differential expression methods when analyzing human population samples
Genome biology
Negative / Null Result Report2020
Purging of highly deleterious mutations through severe bottlenecks in Alpine ibex
Nature Communications
Negative / Null Result Report2011
Single-Cell Genomics Reveals Organismal Interactions in Uncultivated Marine Protists
Science
Negative / Null Result Report2011
Magnetic Resonance Imaging Response Monitoring of Breast Cancer During Neoadjuvant Chemotherapy: Relevance of Breast Cancer Subtype
Journal of Clinical Oncology
Negative / Null Result Report2015
Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children
International Journal of Epidemiology
Negative / Null Result Report2013
Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
PLoS Biology
Negative / Null Result Report2014
Populations of a cyprinid fish are self-sustaining despite widespread feminization of males
BMC Biology
Negative / Null Result Report2018
Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration
Ophthalmology
Negative / Null Result Report2014
Social disadvantage, genetic sensitivity, and children’s telomere length
Proceedings of the National Academy of Sciences
Negative / Null Result Report2020
Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
Nature Communications
Negative / Null Result Report2011
Comparison of two cone beam computed tomographic systems versus panoramic imaging for localization of impacted maxillary canines and detection of root resorption
European Journal of Orthodontics
Negative / Null Result Report2016
A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
Neuro-Oncology
Negative / Null Result Report2010
Genome Wide Analyses Reveal Little Evidence for Adaptive Evolution in Many Plant Species
Molecular Biology and Evolution
Negative / Null Result Report2016
Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces
Cancer Research
Negative / Null Result Report2015
Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice
Journal of Applied Physiology
Negative / Null Result Report2012
Social Transfer of Pathogenic Fungus Promotes Active Immunisation in Ant Colonies
PLoS Biology