Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project
Guillaume Lettre; Cameron D. Palmer; Taylor Young; Kenechi G. Ejebe; Hooman Allayee; Emelia J. Benjamin; Franklyn I. Bennett; Donald W. Bowden · 2011 · PLoS Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, and type-2 diabetes) in individuals of African ancestry, we performed a genome-wide association study (GWAS) in 8,090 African Americans from five population-based cohorts. We replicated 17 loci previously associated with CHD or its risk factors in Caucasians. For five of these regions (CHD: CDKN2A/CDKN2B; HDL-C: FADS1-3, PLTP, LPL, and ABCA1), we could leverage t
Abstract by Guillaume Lettre; Cameron D. Palmer; Taylor Young; Kenechi G. Ejebe; Hooman Allayee; Emelia J. Benjamin; Franklyn I. Bennett; Donald W. Bowden, PLoS Genetics (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pgen.1001300