Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice
Falk Hildebrand; Thi Loan Anh Nguyen; Brigitta M. N. Brinkman; Roberto Garcia Yunta; Bénédicte Cauwe; Peter Vandenabeele; Adrian Liston; Jeroen Raes · 2013 · Genome biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. RESULTS: We find initial evidence for richness-driven, strain-independent murine enterotypes that show a striking resemblance to those in human, and which associate with calp
Abstract by Falk Hildebrand; Thi Loan Anh Nguyen; Brigitta M. N. Brinkman; Roberto Garcia Yunta; Bénédicte Cauwe; Peter Vandenabeele; Adrian Liston; Jeroen Raes, Genome biology (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/gb-2013-14-1-r4