Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces
Mark C. Lloyd; Jessica J. Cunningham; Marilyn M. Bui; Robert J. Gillies; Joel S. Brown; Robert A. Gatenby · 2016 · Cancer Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Spatial heterogeneity in tumors is generally thought to result from branching clonal evolution driven by random mutations that accumulate during tumor development. However, this concept rests on the implicit assumption that cancer cells…
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Metadata source: OpenAlex · DOI 10.1158/0008-5472.can-15-2962