Prophages are infrequently associated with antibiotic resistance in Pseudomonas aeruginosa clinical isolates
Tony H. Chang; Julie D. Pourtois; Naomi L. Haddock; Daisuke Furukawa; Kate E. Kelly; Derek F. Amanatullah; Elizabeth Burgener; Carlos Milla · 2025 · mSphere
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Lysogenic bacteriophages can integrate their genome into the bacterial chromosome in the form of a prophage and can promote genetic transfer between bacterial strains in vitro. However, the contribution of lysogenic bacteriophages to the incidence of antimicrobial resistance (AMR) in clinical settings is poorly understood. Here, in a set of 186 clinical isolates of Pseudomonas aeruginosa collected from respiratory cultures from 82 patients with cystic fibrosis, we evaluate the links between prophage counts and both genomic and phenotypic resistance to six anti-pseudomonal antibiotics:
Abstract by Tony H. Chang; Julie D. Pourtois; Naomi L. Haddock; Daisuke Furukawa; Kate E. Kelly; Derek F. Amanatullah; Elizabeth Burgener; Carlos Milla, mSphere (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1128/msphere.00904-24