Live Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Undergoes an Abortive Replication Cycle in the TG Neurons following Latency Reactivation
Selvaraj Pavulraj; Rhett W. Stout; Daniel B. Paulsen; Shafiqul I. Chowdhury · 2023 · Viruses
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Like other alpha herpesviruses, pseudorabies virus (PRV) establishes lifelong latency in trigeminal ganglionic (TG) neurons. Upon stress, the latent viruses in the TG neurons reactivate and are transported anterograde from the neuron cell bodies to the nerve endings in the nasal mucosa, where they replicate and are discharged in the nasal and oral secretions. Consequently, the virus is transmitted to other naïve animals. This cycle of latency and reactivation continues until the animal dies or is slaughtered. We have constructed a PRV triple mutant virus (PRVtmv) and used it as a live subunit
Abstract by Selvaraj Pavulraj; Rhett W. Stout; Daniel B. Paulsen; Shafiqul I. Chowdhury, Viruses (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/v15020473