The Effect of Dexamethasone-Mediated Atrophy on Mitochondrial Function and BCAA Metabolism During Insulin Resistance in C2C12 Myotubes
Kayla J. Ragland; Kipton B. Travis; Emmalie R. Spry; Toheed Zaman; Pamela M. Lundin; Roger A. Vaughan · 2025 · Metabolites
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background : Muscle loss during sarcopenia and atrophy is also commonly associated with age-related insulin resistance. Interestingly, branched-chain amino acids (BCAA) which are known for stimulating muscle protein synthesis are commonly elevated during insulin resistance and sarcopenic obesity. Objectives : This study investigated the effects of the interplay between atrophy and insulin resistance on insulin sensitivity, mitochondrial metabolism, and BCAA catabolic capacity in a myotube model of skeletal muscle insulin resistance. Methods : C2C12 myotubes were treated with dexamethasone to i
Abstract by Kayla J. Ragland; Kipton B. Travis; Emmalie R. Spry; Toheed Zaman; Pamela M. Lundin; Roger A. Vaughan, Metabolites (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/metabo15050322