A presumed mouse parvovirus with overlooked high toxicity for human primitive CD34+ hematopoietic precursors in vitro and in bone marrow-humanized mice
José C. Segovia; Juan C. Ramírez; Paula Río; Cecilia M. Lotufo; Alberto López-Bueno; Tania Calvo-López; María L. Lamana; Virginia Sandonís · 2025 · Microbiology Spectrum
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Two strains of the minute virus of mice (MVM) parvovirus (of the species Protoparvovirus rodent1), named i (immunosuppressive) and p (prototype), show disparate tropism and pathogenicity in mice. Unlike the virulent MVMi, the MVMp is attenuated and infection-restricted in primary mouse hematopoietic cells; however, it does infect human transformed, established, and stem cells. We thus seek here a putative MVMp natural tropism to humans compared to MVMi. Infectious purified MVMp virions suppress in vitro the clonogenic potential of human committed (erythroid and myeloid) and primitive
Abstract by José C. Segovia; Juan C. Ramírez; Paula Río; Cecilia M. Lotufo; Alberto López-Bueno; Tania Calvo-López; María L. Lamana; Virginia Sandonís, Microbiology Spectrum (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1128/spectrum.02339-25