SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells
Miao Jiang; Pekka Kolehmainen; Laura Kakkola; Sari Maljanen; Krister Melén; Teemu Smura; Ilkka Julkunen; Pamela Österlund · 2021 · Microbiology Spectrum
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT The primary target organ of coronavirus disease 2019 (COVID-19) infection is the respiratory tract. Currently, there is limited information on the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect and regulate innate immunity in human immune cells and lung epithelial cells. Here, we compared the ability of four Finnish isolates of SARS-CoV-2 from COVID-19 patients to replicate and induce interferons (IFNs) and other cytokines in different human cells. All isolates failed to replicate in dendritic cells, macrophages, monocytes, and lymphocytes, and no in
Abstract by Miao Jiang; Pekka Kolehmainen; Laura Kakkola; Sari Maljanen; Krister Melén; Teemu Smura; Ilkka Julkunen; Pamela Österlund, Microbiology Spectrum (2021) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Pleiotropic effects of Mentha longifolia L. extract on the regulation of genes involved in inflammation and apoptosis induced by Clostridioides difficile ribotype 001
Negative / Null Result ReportClofazimine inhibits innate immunity against Mycobacterium tuberculosis by NF-κB
Negative / Null Result ReportThe Effect of Dexamethasone-Mediated Atrophy on Mitochondrial Function and BCAA Metabolism During Insulin Resistance in C2C12 Myotubes
Negative / Null Result ReportLive Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Undergoes an Abortive Replication Cycle in the TG Neurons following Latency Reactivation
Negative / Null Result ReportSeroprevalence of Mycoplasma genitalium among Fertile and Infertile Women at Murtala Muhammad Specialist Hospital, Kano
Negative / Null Result ReportPopulation dynamics of Brachionus calyciflorus driven by the associated natural bacterioplankton
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1128/spectrum.00774-21