cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation
John C. Martinez; Francesco Morandini; Cheyenne Rechsteiner; Lucinda Fitzgibbons; Natasha Sieczkiewicz; Xiaoyan Liao; Weijie He; Sung Jae Bae · 2026 · Nature Aging
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Aging-associated inflammation, or 'inflammaging" is a driver of multiple age-associated diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to activate interferon response upon detecting viral DNA in the…
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Metadata source: OpenAlex · DOI 10.1038/s43587-026-01206-y