An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment
Liangzhan sun; Xiaojing Chu; Tingting Kong; Xirui Chen; Jianing Ru; Qianqian Gao; Wei Zhou; Xiliang Wang · 2026 · Immunity
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Tumor-associated macrophages (TAMs) can suppress antitumor immunity and reduce responses to immune checkpoint blockade (ICB). Here, we asked how TAM programs contribute to ICB non-response. Integration of public single-cell RNA sequencing (scRNA-seq) datasets across 12 cancer types identified SPP1 + TAMs as a tumor-enriched macrophage subset with immunosuppressive features. TAMs from ICB non-responders across multiple tumor types exhibited higher SPP1 expression. In murine models, macrophage Spp1 deletion suppressed tumor growth and prolonged survival and was associated with a remodeled tumor
Abstract by Liangzhan sun; Xiaojing Chu; Tingting Kong; Xirui Chen; Jianing Ru; Qianqian Gao; Wei Zhou; Xiliang Wang, Immunity (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.immuni.2026.04.001