Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy
Koen H.M. Prange; Gemma Bel-Bordes; MAC Depuydt; Panos Barlampas; Moritz Reif; Max L.B. Grönloh; Rosalie W.M. Kempkes; Guillermo R. Griffith · 2026 · European Heart Journal
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage data. Moreover, to date no direct link has been established between cellular content of atherosclerotic lesions and secondary clinical outcome. This study is aimed at characterization of atherosclerot
Abstract by Koen H.M. Prange; Gemma Bel-Bordes; MAC Depuydt; Panos Barlampas; Moritz Reif; Max L.B. Grönloh; Rosalie W.M. Kempkes; Guillermo R. Griffith, European Heart Journal (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/eurheartj/ehag117