The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications
Marcello Candelli; Marta Sacco Fernandez; Gloria Rozzi; Giorgio Sodero; Andrea Piccioni; Giulia Pignataro; Donato Rigante; Francesco Franceschi · 2025 · Diagnostics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background and Objectives: Despite major advances in medical science and critical care, sepsis remains a leading cause of morbidity and mortality worldwide: it arises from dysregulated host response to infections and may culminate in organ dysfunction. A hallmark of its pathogenesis is the cytokine storm, in which interleukins (ILs) serve as central mediators of both protective and deleterious immune responses. This review summarizes the current knowledge on the role of ILs in sepsis, emphasizing their potential as biomarkers and therapeutic targets. Material and Methods: We analyzed recent cl
Abstract by Marcello Candelli; Marta Sacco Fernandez; Gloria Rozzi; Giorgio Sodero; Andrea Piccioni; Giulia Pignataro; Donato Rigante; Francesco Franceschi, Diagnostics (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/diagnostics15222927