The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner
Madeleine P. J. White; Chris Johnston; John R. Grainger; Joanne E. Konkel; Richard A. O’Connor; Stephen M. Anderton; Rick M. Maizels · 2020 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimise excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases. Multiple sclerosis (MS) is a severe autoimmune disease characterised by inflammatory lesions within the central nervous system; there are very limited therapeutic options for the progressive forms of the disease and none are curative. Here, we used the experimental autoimmune encephalomyelitis (EAE) model to examine if the intestinal helminth He
Abstract by Madeleine P. J. White; Chris Johnston; John R. Grainger; Joanne E. Konkel; Richard A. O’Connor; Stephen M. Anderton; Rick M. Maizels, Frontiers in Immunology (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2020.01830