A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease
Clara Young; Mandeep Singh; Katherine Jackson; Matthew A. Field; Timothy J. Peters; Stefano Angioletti‐Uberti; Daan Frenkel; Shyamsundar Ravishankar · 2025 · Immunity
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immu
Abstract by Clara Young; Mandeep Singh; Katherine Jackson; Matthew A. Field; Timothy J. Peters; Stefano Angioletti‐Uberti; Daan Frenkel; Shyamsundar Ravishankar, Immunity (2025) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level
Negative / Null Result ReportDamaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections
Negative / Null Result ReportEffects of Bacillus subtilis on the growth performance, digestive enzymes, immune gene expression and disease resistance of white shrimp, Litopenaeus vannamei
Negative / Null Result ReportBCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
Negative / Null Result ReportFucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
Negative / Null Result ReportGlobal Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1016/j.immuni.2024.12.011