Ixekizumab With or Without Tirzepatide in Adults With Psoriasis and Overweight or Obesity
M Lebwohl; Andrew Blauvelt; Cynthia E. Kartman; Cianna Leatherwood; Kenneth B. Gordon; Naveed Sattar; Luis Puig; Joseph F. Merola · 2026 · JAMA Dermatology
WASTE classifies this as Replication Failure · AI classification, approximate
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Abstract
Importance: Overweight and obesity affect 60% to 78% of patients with psoriasis, affecting disease severity, treatment response, and clinical outcomes. However, no large, randomized, active-controlled clinical trial has evaluated a treatment strategy that addresses both diseases simultaneously. Objective: To evaluate the efficacy and safety of ixekizumab with or without tirzepatide in participants with psoriasis and overweight or obesity. Design, Setting, and Participants: This phase 3b, randomized, open-label, 52-week clinical trial was conducted at 72 sites in the US in adults with moderate
Abstract by M Lebwohl; Andrew Blauvelt; Cynthia E. Kartman; Cianna Leatherwood; Kenneth B. Gordon; Naveed Sattar; Luis Puig; Joseph F. Merola, JAMA Dermatology (2026) — licensed CC BY-SA 4.0.
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Metadata source: OpenAlex · DOI 10.1001/jamadermatol.2026.1753