Efficacy of the meningococcal vaccine against Neisseria gonorrhoeae: a randomised clinical trial (MenGO)
Caroline Thng; Sharareh Eskandari; Fengyi Jin; Ian Hughes; Andrew E. Grulich; Maree O’Sullivan; Evgeny A. Semchenko; Kate L. Seib · 2026 · npj Vaccines
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Neisseria gonorrhoeae (NG) causes significant morbidity globally, and no licensed vaccine currently exists. Observational studies suggest the four-component meningococcal B (4CMenB) vaccine may provide cross-protection against NG. We conducted MenGO, an open-label, randomized controlled trial to evaluate the efficacy, safety, and immunogenicity of 4CMenB against NG in gay and bisexual men (GBM). Participants were randomized 1:1 to receive two doses of 4CMenB, or no vaccine, and were followed for 2 years with 3-monthly visits. 4CMenB vaccination did not significantly reduce gonorrhoea incidence
Abstract by Caroline Thng; Sharareh Eskandari; Fengyi Jin; Ian Hughes; Andrew E. Grulich; Maree O’Sullivan; Evgeny A. Semchenko; Kate L. Seib, npj Vaccines (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41541-026-01422-y