Replication Failure2022
Reproducible brain-wide association studies require thousands of individuals
Nature
Failure-mode index
Negative results in Neuroscience
243 indexed negative results, null findings, and replication failures in Neuroscience. Each entry is a real published study whose primary finding was negative — learn what already failed before you repeat it.
Most-cited failures in Neuroscience
Negative / Null Result Report2010
Daily Left Prefrontal Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder
Archives of General Psychiatry
Negative / Null Result Report2011
Early Brain Overgrowth in Autism Associated With an Increase in Cortical Surface Area Before Age 2 Years
Archives of General Psychiatry
Negative / Null Result Report2020
Objective evaluation of anosmia and ageusia in COVID‐19 patients: Single‐center experience on 72 cases
Head & Neck
Negative / Null Result Report2011
Polarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning
Neuropsychologia
Negative / Null Result Report2013
The feedback-related negativity (FRN) revisited: New insights into the localization, meaning and network organization
NeuroImage
Negative / Null Result Report2010
Beyond good and evil: The time-course of neural activity elicited by specific picture content.
Emotion
Negative / Null Result Report2013
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
Molecular Neurodegeneration
Negative / Null Result Report2013
Structural analysis and mapping of individual protein complexes by infrared nanospectroscopy
Nature Communications
Negative / Null Result Report2020
Multimodality neuroimaging brain-age in UK biobank: relationship to biomedical, lifestyle, and cognitive factors
Neurobiology of Aging
Negative / Null Result Report2012
Individual common variants exert weak effects on the risk for autism spectrum disorders
Human Molecular Genetics
Negative / Null Result Report2011
Age-related changes in the default mode network are more advanced in Alzheimer disease
Neurology
Negative / Null Result Report2012
Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study
PEDIATRICS
Negative / Null Result Report2010
Sensory features and repetitive behaviors in children with autism and developmental delays
Autism Research
Negative / Null Result Report2010
Intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder: a randomized controlled trial
Journal of Child Psychology and Psychiatry
Negative / Null Result Report2010
Sexual Dimorphism in the Fly Brain
Current Biology
Negative / Null Result Report2014
Factorial comparison of working memory models.
Psychological Review
Negative / Null Result Report2016
Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
Nature Communications
Negative / Null Result Report2011
Academic Performance in Adolescence after Inguinal Hernia Repair in Infancy
Anesthesiology
Negative / Null Result Report2015
Revisiting the Evidence for Collapsing Boundaries and Urgency Signals in Perceptual Decision-Making
Journal of Neuroscience
Negative / Null Result Report2019
Deep neural networks and kernel regression achieve comparable accuracies for functional connectivity prediction of behavior and demographics
NeuroImage
Negative / Null Result Report2020
Different scaling of linear models and deep learning in UKBiobank brain images versus machine-learning datasets
Nature Communications
Negative / Null Result Report2012
The Influence of Socioeconomic Status on Children’s Brain Structure
PLoS ONE
Negative / Null Result Report2018
Large-scale replication study reveals a limit on probabilistic prediction in language comprehension
eLife
Negative / Null Result Report2012
A Test of The Relation Between Working-Memory Capacity and Syntactic Island Effects
Language
Negative / Null Result Report2010
Distributed neural system for general intelligence revealed by lesion mapping
Proceedings of the National Academy of Sciences
Negative / Null Result Report2011
Testing theories of post-error slowing
Attention Perception & Psychophysics
Failed Experiment Report2015
Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double‐blind, randomized, controlled trial
Annals of Neurology
Negative / Null Result Report2011
Cellular-Resolution Population Imaging Reveals Robust Sparse Coding in the Drosophila Mushroom Body
Journal of Neuroscience
Negative / Null Result Report2019
Empirical failures of the claim that autistic people lack a theory of mind.
Archives of Scientific Psychology
Negative / Null Result Report2015
Rethinking the role of sham TMS
Frontiers in Psychology
Negative / Null Result Report2010
A multimodal approach to emotion recognition ability in autism spectrum disorders
Journal of Child Psychology and Psychiatry
Negative / Null Result Report2019
The Role of Microglia and Astrocytes in Huntington’s Disease
Frontiers in Molecular Neuroscience
Negative / Null Result Report2016
Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures
Psychoneuroendocrinology
Negative / Null Result Report2016
DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases
Annals of Neurology
Negative / Null Result Report2016
Distinct Mechanisms for Distractor Suppression and Target Facilitation
Journal of Neuroscience
Negative / Null Result Report2013
Effects of Aromatherapy on the Anxiety, Vital Signs, and Sleep Quality of Percutaneous Coronary Intervention Patients in Intensive Care Units
Evidence-based Complementary and Alternative Medicine
Failed Experiment Report2013
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients
Neurology
Negative / Null Result Report2014
Brain-derived neurotrophic factor (BDNF) as a potential mechanism of the effects of acute exercise on cognitive performance
Journal of sport and health science/Journal of Sport and Health Science
Negative / Null Result Report2015
Human observers have optimal introspective access to perceptual processes even for visually masked stimuli
eLife
Negative / Null Result Report2014
The Animacy Continuum in the Human Ventral Vision Pathway
Journal of Cognitive Neuroscience
Negative / Null Result Report2010
Stimulus-Specific Adaptation in Auditory Cortex Is an NMDA-Independent Process Distinct from the Sensory Novelty Encoded by the Mismatch Negativity
Journal of Neuroscience
Negative / Null Result Report2011
Independent HHsearch, Needleman-Wunsch-Based, and Motif Analyses Reveal the Overall Hierarchy for Most of the G Protein-Coupled Receptor Families
Molecular Biology and Evolution
Negative / Null Result Report2021
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain
Neurobiology of Aging
Negative / Null Result Report2011
The Number and Quality of Representations in Working Memory
Psychological Science
Negative / Null Result Report2011
Is Gamma-Band Activity in the Local Field Potential of V1 Cortex a "Clock" or Filtered Noise?
Journal of Neuroscience
Negative / Null Result Report2013
Tracking target and distractor processing in fixed-feature visual search: Evidence from human electrophysiology.
Journal of Experimental Psychology Human Perception & Performance
Negative / Null Result Report2012
Tinnitus does not require macroscopic tonotopic map reorganization
Frontiers in Systems Neuroscience
Failed Experiment Report2016
Quantifying Neural Oscillatory Synchronization: A Comparison between Spectral Coherence and Phase-Locking Value Approaches
PLoS ONE
Negative / Null Result Report2011
Multistability and Perceptual Inference
Neural Computation