The Role of Microglia and Astrocytes in Huntington’s Disease
Thulani H. Palpagama; Henry J. Waldvogel; Richard L. M. Faull; Andrea Kwakowsky · 2019 · Frontiers in Molecular Neuroscience
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD patients present with movement disorders, behavioral and psychiatric symptoms and cognitive decline. This review summarizes the contribution of microglia and astrocytes to HD pathophysiology. Neuroinflammation in the HD brain is characterized by a reactive morphology in these glial cells. Microglia and astrocytes are critical in regulating neuronal activity and maintaining an optimal milieu for neuronal function. Previous studies provide evidence that activated microglia and reactive astrocytes contribute to HD pa
Abstract by Thulani H. Palpagama; Henry J. Waldvogel; Richard L. M. Faull; Andrea Kwakowsky, Frontiers in Molecular Neuroscience (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fnmol.2019.00258