Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
Donna M. Werling; Neelroop Parikshak; Daniel H. Geschwind · 2016 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Autism spectrum disorder (ASD) is more prevalent in males, and the mechanisms behind this sex-differential risk are not fully understood. Two competing, but not mutually exclusive, hypotheses are that ASD risk genes are sex-differentially regulated, or alternatively, that they interact with characteristic sexually dimorphic pathways. Here we characterized sexually dimorphic gene expression in multiple data sets from neurotypical adult and prenatal human neocortical tissue, and evaluated ASD risk genes for evidence of sex-biased expression. We find no evidence for systematic sex-differential ex
Abstract by Donna M. Werling; Neelroop Parikshak; Daniel H. Geschwind, Nature Communications (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/ncomms10717