Hypoxic Training Ameliorates Skeletal Muscle Microcirculation Vascular Function in a Sirt3-Dependent Manner
Chunwei Ma; Chunwei Ma; Yongcai Zhao; Xiaoqing Ding; Binghong Gao · 2022 · Frontiers in Physiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Hypoxic training improves the microcirculation function of human skeletal muscle, but its mechanism is still unclear. Silent information regulator 2 homolog 3 (Sirt3) can improve mitochondrial function and oxidative status. We aimed to examine the role of Sirt3 in the process of hypoxic training, which affects skeletal muscle microcirculation. C57BL/6 mice were assigned to control (C), hypoxic training (HT), Sirt3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP), and 3-TYP + hypoxic training (3-TYP + HT) groups (n = 6/group). Sirt3 inhibition was induced by intraperitoneal injection of Sir
Abstract by Chunwei Ma; Chunwei Ma; Yongcai Zhao; Xiaoqing Ding; Binghong Gao, Frontiers in Physiology (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fphys.2022.921763