Effect of metformin on transcriptome and adipokinome of adipocytes of local fat deposts of patients with ischemic heart disease
Yu. A. Dyleva; O. V. Gruzdeva; E. V. Belik; D. A. Borodkina; M. Yu. Sinitskiy; S. V. Ivanov; O. L. Barbarash · 2023 · Ожирение и метаболизм
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The information available to date on the effect of metformin on the transcriptome and secretory capacity of adipocytes in human adipose tissue (AT) is scarce and contradictory. The study analyzed whether metformin in vitro modulates gene expression and secretion of adiponectin and leptin in the AT of subcutaneous (SAT), epicardial (EAT) and perivascular (PVAT) localization of patients with ischemic artery disease (IHD).AIM: To assess the effect of metformin at various concentrations (1 and 10 mmol / L) on the level of expression of adiponectin and leptin genes and their content in
Abstract by Yu. A. Dyleva; O. V. Gruzdeva; E. V. Belik; D. A. Borodkina; M. Yu. Sinitskiy; S. V. Ivanov; O. L. Barbarash, Ожирение и метаболизм (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.14341/omet12743