Modeling age‐dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids
Mahmoud A. Mohammad; Inka C. Didelija; Barbara Stoll; Douglas G. Burrin; Juan C. Marini · 2020 · Physiological Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Abstract Background Age‐dependent changes in the intestinal gene expression of enzymes involved in the metabolism of citrulline and arginine are well characterized. Enteroids, a novel ex‐vivo model that recreates the three‐dimensional structure of the intestinal crypt‐villus unit, have shown to replicate molecular and physiological profiles of the intestinal segment from where they originated (“location memory”). Objective The present study tested the hypothesis that enteroids recapitulate the developmental changes observed in vivo regarding citrulline production in pigs (“developmental memory
Abstract by Mahmoud A. Mohammad; Inka C. Didelija; Barbara Stoll; Douglas G. Burrin; Juan C. Marini, Physiological Reports (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.14814/phy2.14565