Modification of albendazole pharmacokinetics by menbutone administration in calves
E. Milena Vazquez; Beatriz Romero; Raquel Diez; Cristina Lopez; Jose M. Rodriguez; Nelida Fernandez; M. Jose Diez; Ana M. Sahagun · 2026 · Frontiers in Veterinary Science
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Abstract
Optimizing the use of the existing anthelmintics has become a priority, as resistance is a growing concern worldwide and the development of novel antiparasitic drugs slow. The paper describes the pharmacokinetic interaction between the antiparasitic albendazole (ABZ) and the choleretic drug menbutone (MEN) in calves, when ABZ was administered orally (7.5 mg/kg) alone or with intramuscular MEN (10 mg/kg) (1 or 2 doses 24 h apart) to 12 animals. Blood samples were collected at 14 sampling points over 72 h, and plasma concentrations of ABZ, albendazole sulfoxide (ABZSO, active metabolite), and al
Abstract by E. Milena Vazquez; Beatriz Romero; Raquel Diez; Cristina Lopez; Jose M. Rodriguez; Nelida Fernandez; M. Jose Diez; Ana M. Sahagun, Frontiers in Veterinary Science (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fvets.2026.1834486