Optimisation of ketamine‐xylazine anaesthetic dose and its association with changes in the dendritic spine of CA1 hippocampus in the young and old male and female Wistar rats
Narges Sotoudeh; Mohammad Reza Namavar · 2022 · Veterinary Medicine and Science
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background A combination of ketamine‐xylazine (K‐X) is frequently used for anaesthesia in rats. Sex and age affect this cocktail dosage. Ketamine causes a hypnotic effect by blocking NMDA receptors located on the dendritic spine of the CA1 region. Objectives The present study aimed to find the optimal dosage of K‐X and its association with the changes in dendritic spine number of the CA1 region for aged and young rats of both sexes. Methods We injected 150–4 mg/kg of K‐X in young and 100–2 mg/kg in aged Wistar rats intraperitoneally and recorded the onset time and duration of anaesthe
Abstract by Narges Sotoudeh; Mohammad Reza Namavar, Veterinary Medicine and Science (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/vms3.936