Mitochondrial ROS Accumulation Contributes to Maternal Hypertension and Impaired Remodeling of Spiral Artery but Not IUGR in a Rat PE Model Caused by Maternal Glucocorticoid Exposure
Jing Long; Yan Huang; Gang Wang; Zhengshan Tang; Yali Shan; Shiping Shen; Xin Ni · 2023 · Antioxidants
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system
Abstract by Jing Long; Yan Huang; Gang Wang; Zhengshan Tang; Yali Shan; Shiping Shen; Xin Ni, Antioxidants (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/antiox12050987