GLP 1 Regulated Intestinal Cell’s Insulin Expression and Selfadaptation before the Onset of Type 2 Diabetes
Shivani Srivastava; Harsh Pandey; Surya Kumar Singh; Yamini Bhusan Tripathi · 2019 · Advanced Pharmaceutical Bulletin
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Purpose: Basically insulin is known to be secreted by β cells of the pancreas. Recently, it has also been found to be produced and expressed by intestinal epithelial cells with the help of L cells secreting glucagon like peptide 1 (GLP 1). Here, we have studied the same intestinal insulin expression property in T2D rats. Methods: Following 2 weeks of high fat diet (HFD) consumption, we have been given a single dose of streptozotocin (STZ) (35 mg/kg bw). Rats were then sacrificed after 1, 7 and 21 days. The GLP 1 analogue, liraglutide was also given to one group of diabetic rats, upto their res
Abstract by Shivani Srivastava; Harsh Pandey; Surya Kumar Singh; Yamini Bhusan Tripathi, Advanced Pharmaceutical Bulletin (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.15171/apb.2019.039