18β-Glycyrrhetinic Acid Induces Metabolic Changes and Reduces Staphylococcus aureus Bacterial Cell-to-Cell Interactions
Alan J. Weaver; Timothy R. Borgogna; Galen O’Shea-Stone; Tami R. Peters; Valérie Copié; Jovanka Voyich; Martin Teintze · 2022 · Antibiotics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The rise in bacterial resistance to common antibiotics has raised an increased need for alternative treatment strategies. The natural antibacterial product, 18β-glycyrrhetinic acid (GRA) has shown efficacy against community-associated methicillin-resistant Staphylococcus aureus (MRSA), although its interactions against planktonic and biofilm modes of growth remain poorly understood. This investigation utilized biochemical and metabolic approaches to further elucidate the effects of GRA on MRSA. Prolonged exposure of planktonic MRSA cell cultures to GRA resulted in increased production of staph
Abstract by Alan J. Weaver; Timothy R. Borgogna; Galen O’Shea-Stone; Tami R. Peters; Valérie Copié; Jovanka Voyich; Martin Teintze, Antibiotics (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/antibiotics11060781