Heart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain.
Hilton Antônio Mata-Santos; Camila Victória Sousa Oliveira; Daniel F Feijo; Daniel Figueiredo Vanzan; Glaucia Vilar-Pereira; Isalira P Ramos; Vitor Coutinho Carneiro; Oscar Moreno-Loaiza · 2024 · PLoS Neglected Tropical Diseases
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Abstract
Oxidative stress promotes T. cruzi growth and development of chronic Chagas heart dysfunction. However, the literature contains gaps that must be fulfilled, largely due to variations in parasite DTU sources, cell types, mouse strains, and tools to manipulate redox status. We assessed the impact of oxidative environment on parasite burden in cardiomyoblasts and the effects of the Nrf2-inducer COPP on heart function in BALB/c mice infected with either DTU-II Y or DTU-I Colombian T. cruzi strains. Treatment with antioxidants CoPP, apocynin, resveratrol, and tempol reduced parasite burden in cardi
Abstract by Hilton Antônio Mata-Santos; Camila Victória Sousa Oliveira; Daniel F Feijo; Daniel Figueiredo Vanzan; Glaucia Vilar-Pereira; Isalira P Ramos; Vitor Coutinho Carneiro; Oscar Moreno-Loaiza, PLoS Neglected Tropical Diseases (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pntd.0012612