Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.
María Ailén Natale; Todd Minning; María Cecilia Albareda; Melisa Daiana Castro Eiro; María Gabriela Álvarez; Bruno Lococo; Gonzalo Cesar; Graciela Bertocchi · 2021 · PLoS Neglected Tropical Diseases
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other cytokines of the IL-12 family and might be involved in the transcriptional regulation of T-cell function. Here, we evaluated the expression and function of IL-27R in antigen-experienced T cells from subjects with chronic Chagas disease and assessed whether in vitro treatment with IL-27 and IL-7 migh
Abstract by María Ailén Natale; Todd Minning; María Cecilia Albareda; Melisa Daiana Castro Eiro; María Gabriela Álvarez; Bruno Lococo; Gonzalo Cesar; Graciela Bertocchi, PLoS Neglected Tropical Diseases (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pntd.0009473