Association of SCN1A and SCN2A Gene Polymorphisms with Antiseizure Medication Responsiveness: A Case-Control Study from Eastern India
Kollipara Sumanth; Uma Sinharoy; Anindita Joardar; Sarnava Roy; Alak Pandit; Gautam Gangopadhyay · 2026 · Annals of Indian Academy of Neurology
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Abstract
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
Abstract by Kollipara Sumanth; Uma Sinharoy; Anindita Joardar; Sarnava Roy; Alak Pandit; Gautam Gangopadhyay, Annals of Indian Academy of Neurology (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.4103/aian.aian_616_25