Breadth of tuning in taste afferent neurons varies with stimulus strength
An Wu; Gennady Dvoryanchikov; Elizabeth Pereira; Nirupa Chaudhari; Stephen D. Roper · 2015 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory afferent neurons. Whether each taste quality (sweet, bitter and so on) is encoded by separate neurons ('labelled lines') remains controversial. We used mice expressing GCaMP3 in geniculate ganglion sensory neurons to investigate taste-evoked activity. Using confocal calcium imaging, we recorded responses to oral stimulation with prototypic taste stimuli. Up to 69% of neurons respond to multiple tastants. Moreover, neurons tuned to a single taste quality at low concentration become more broadly tuned when
Abstract by An Wu; Gennady Dvoryanchikov; Elizabeth Pereira; Nirupa Chaudhari; Stephen D. Roper, Nature Communications (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/ncomms9171