Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial
James A. Berkley; Moses M. Ngari; Johnstone Thitiri; Laura Mwalekwa; Molline Timbwa; Fauzat Hamid; Rehema Ali; Jimmy Shangala · 2016 · The Lancet Global Health
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Children with complicated severe acute malnutrition (SAM) have a greatly increased risk of mortality from infections while in hospital and after discharge. In HIV-infected children, mortality and admission to hospital are prevented by daily co-trimoxazole prophylaxis, despite locally reported bacterial resistance to co-trimoxazole. We aimed to assess the efficacy of daily co-trimoxazole prophylaxis on survival in children without HIV being treated for complicated SAM. METHODS: We did a multicentre, double-blind, randomised, placebo-controlled study in four hospitals in Kenya (two r
Abstract by James A. Berkley; Moses M. Ngari; Johnstone Thitiri; Laura Mwalekwa; Molline Timbwa; Fauzat Hamid; Rehema Ali; Jimmy Shangala, The Lancet Global Health (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/s2214-109x(16)30096-1