Effect of Linagliptin and Voglibose on metabolic profile in patients with Type 2 Diabetes: a randomized, double-blind, placebo-controlled trial
Girish Parthan; Shobhit Bhansali; Anura V. Kurpad; Rama Walia; Kishor Bhat; Anil Bhansali · 2018 · BMC Pharmacology and Toxicology
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Abstract
Abstract Background Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control by promoting GLP1-mediated glucose-dependent insulin secretion and suppression of glucagon. Sitagliptin and vildagliptin have been shown to improve insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). However, these patients had uncontrolled blood glucose at inclusion; therefore, the improvement in insulin sensitivity observed in these studies could be attributed to the drug per se and/or reduction in glucotoxicity. This study examines the effect of linagliptin on insulin sensitivity and β-ce
Abstract by Girish Parthan; Shobhit Bhansali; Anura V. Kurpad; Rama Walia; Kishor Bhat; Anil Bhansali, BMC Pharmacology and Toxicology (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s40360-018-0228-z