Efficacy and Safety of Zabedosertib, an Interleukin-1 Receptor-Associated Kinase 4 Inhibitor, in Patients with Moderate-to-Severe Atopic Dermatitis: A Phase II Randomized Study
Stefan J. Jodl; Margitta Worm; Frauke Friedrichs; Ulrike Heinzel-Pleines; Andrea Wagenfeld; Maximilian Feldmüller; Stefan Klein; Ruiping Zhang · 2025 · Dermatology and Therapy
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Abstract
Abstract Introduction Interleukin-1 receptor-associated kinase 4 (IRAK4) is expressed in various immune cells and regulates proinflammatory cytokine production. Its inhibition represents a novel, promising therapeutic option in the treatment of atopic dermatitis (AD). Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor that suppresses markers of local and systemic immune responses. This study aimed to evaluate the efficacy and safety of zabedosertib in adults with moderate-to-severe AD. Methods DAMASK was a randomized, double-blind, 12-week, placebo-controlled, phase 2a, proof-of-
Abstract by Stefan J. Jodl; Margitta Worm; Frauke Friedrichs; Ulrike Heinzel-Pleines; Andrea Wagenfeld; Maximilian Feldmüller; Stefan Klein; Ruiping Zhang, Dermatology and Therapy (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1007/s13555-025-01505-z