CSF neurofilament light chain but not FLT3 ligand discriminates Parkinsonian disorders
Megan Kristy Herbert; Marjolein B Aerts; Marijke eBeenes; Niklas eNorgren; Rianne A J Esselink; Bastiaan R Bloem; H Bea eKuiperij; Marcel M Verbeek · 2015 · Frontiers in Neurology
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Abstract
The differentiation between multiple system atrophy (MSA) and Parkinson’s disease (PD) is difficult, particularly in early disease stages. Therefore, we aimed to evaluate the diagnostic value of neurofilament light chain (NFL), fms-like tyrosine kinase ligand (FLT3L) and total tau protein (t-tau) in cerebrospinal fluid (CSF) as biomarkers to discriminate MSA from PD. Using commercially available enzyme-linked immunoassays (ELISAs), we measured CSF levels of NFL, FLT3L and t-tau in a discovery cohort of 36 PD patients, 27 MSA patients and 57 non-neurological controls and in a validation cohort
Abstract by Megan Kristy Herbert; Marjolein B Aerts; Marijke eBeenes; Niklas eNorgren; Rianne A J Esselink; Bastiaan R Bloem; H Bea eKuiperij; Marcel M Verbeek, Frontiers in Neurology (2015) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fneur.2015.00091