An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
Yabe Ichiro; Miyagishi Ryuji; Fukazawa Toshiyuki; Kikuchi Seiji; Niino Masaaki; Tashiro Kunio · 2002 · BMC Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Abstract Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. Methods Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP
Abstract by Yabe Ichiro; Miyagishi Ryuji; Fukazawa Toshiyuki; Kikuchi Seiji; Niino Masaaki; Tashiro Kunio, BMC Neurology (2002) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1471-2377-2-8