The global Alzheimer's Association round robin study on plasma amyloid β methods
Josef Pannee; Leslie M. Shaw; Magdalena Korecka; Teresa Waligorska; Charlotte E. Teunissen; Erik Stoops; Hugo M. J. Vanderstichele; Kimberley Mauroo · 2021 · Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Introduction Blood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)–based assays currently used in clinical settings. In this study, we examined different blood‐based assays to measure Aβ and how they compare among centers and assays. Methods Aliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass‐spectrometric methods were used to measure plasma Aβ concentrations. Results Correlations were weak for Aβ42 while Aβ40 correlations were stronger. The rati
Abstract by Josef Pannee; Leslie M. Shaw; Magdalena Korecka; Teresa Waligorska; Charlotte E. Teunissen; Erik Stoops; Hugo M. J. Vanderstichele; Kimberley Mauroo, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/dad2.12242