Population Pharmacokinetics and Exposure–Response Analysis of Serplulimab in Small Cell Lung Cancer Patients
Kun Wang; Yuanyuan Shen; Chen Hu; Fengyan Xu; Qingyu Wang; Yuying Gao; Liang Zhou · 2025 · Clinical and Translational Science
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT While PD‐L1 antibodies have demonstrated efficacy in small cell lung cancer, the therapeutic benefits remain limited. To address this unmet medical need, serplulimab was developed as an innovative monoclonal antibody targeting PD‐1. This study evaluated the pharmacokinetic (PK) properties of serplulimab and their relationship with efficacy and safety in patients with extensive‐stage small cell lung cancer (ES‐SCLC), using population pharmacokinetics (PopPK) and exposure–response (E–R) analysis to inform dose selection. Data from 1144 patients across eight Phase I–III clinical trials s
Abstract by Kun Wang; Yuanyuan Shen; Chen Hu; Fengyan Xu; Qingyu Wang; Yuying Gao; Liang Zhou, Clinical and Translational Science (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1111/cts.70322