Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs
Nilsson KF; Goździk W; Frostell C; Zieliński S; Zielińska M; Ratajczak K; Skrzypczak P; Rodziewicz S · 2018 · Drug Design, Development and Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Kristofer F Nilsson,1,2 Waldemar Goździk,3 Claes Frostell,4 Stanisław Zieliński,3 Marzena Zielińska,3 Kornel Ratajczak,5 Piotr Skrzypczak,5 Sylwia Rodziewicz,5 Johanna Albert,6 Lars E Gustafsson1,† 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 2Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 3Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland; 4Department of Anesthesia and Intensive Care, Danderyd Hospital, Stockholm, Swede
Abstract by Nilsson KF; Goździk W; Frostell C; Zieliński S; Zielińska M; Ratajczak K; Skrzypczak P; Rodziewicz S, Drug Design, Development and Therapy (2018) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Changes in Essential Oil Content and Yield of Basil in Response to Different Levels of Nitrogen and Plant Density
Negative / Null Result Report18β-Glycyrrhetinic Acid Induces Metabolic Changes and Reduces Staphylococcus aureus Bacterial Cell-to-Cell Interactions
Negative / Null Result ReportInteraction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach
Negative / Null Result ReportDrug Interaction Potential of Berberine Hydrochloride When Co-Administered with Tofacitinib and Filgotinib in Rats
Negative / Null Result ReportImpaired Upper Airway Muscle Function with Excessive or Deficient Dietary Intake of Selenium in Rats
Negative / Null Result ReportGLP 1 Regulated Intestinal Cell’s Insulin Expression and Selfadaptation before the Onset of Type 2 Diabetes
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ